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Final Report/Thesis 2019
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===Methods=== In task 2, the project has conducted DNA match examination on Somerton Man's DNA kit with multiple methods, but there is no match results for the his DNA reference file. In this task, one-to-many tool will be used again on 2 sample DNA files the project ordered from 23andMe, and the match results shall be recorded. Then the DNA match tests would be conducted on the degraded files created in task 3. The top 30 match results for each degraded DNA kit would be recorded and compare with the results of their original kit. A false positives and false negatives test would be conducted to show the change of match results during the degradation process. In this case, false positives would be match kits that are in the degraded kit's match results but not in original kit's result. And false negatives would present kits that are matched with original kit but not with the degraded one. An example is presented for a clear understanding. There are 5 kits A, B, C, D and E matched with the original kit, and kits A, B, C, M and N are matched with a degraded kit. Then the false positives for this degraded kit are D and E, and the false negatives are kits M and N. A line graphs of the number of false positives and false negatives against the percentage of SNPs removed will be created to show how degradation process effect the match results.
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